In both men and women, common causes of urethral pain include sexually transmitted diseases (STDs), urinary tract infections (UTIs), urethritis(inflammation of the urethra), urethral syndrome(discomfort in the tube carrying urine outside the body), urethral cancer, urethral carbuncle(mass in the urethra usually in menopausal females), prostatitis(in men as the urethra passes through the prostate).