Pancreatic cancer is one of the leading cause of deaths due to cancer in the world and is very difficult to treat as it is usually not diagnosed in early stages. The most common system used to stage pancreatic cancer is AJCC (American Joint Committee on Cancer) TNM system, which is based on 3 main pieces of information:
- The extent of the tumor (T): How large is the tumor and has it grown outside the pancreas into nearby blood vessels
- Spread to nearby lymph nodes (N): Has the cancer spread to nearby lymph nodes and how many of them if yes?
- Metastasis to distant sites (M): Has the cancer spread to distant lymph nodes or organs?
The system that is accepted since January 2018 is as follows:
Stage 0: The cancer is confined to the top layers of the pancreatic duct cells and has not invaded deeper tissues. It has not spread outside pancreas and hence no involvement of nearby lymph nodes or distant sites.
Stage IA: The cancer is confined to the pancreas and is not bigger than 2 cm. There is no involvement of nearby lymph nodes or distant sites.
Stage IB: The cancer is confined to the pancreas and is larger than 2 cm but not more than 4 cm. There is no involvement of nearby lymph nodes or distant sites.
Stage IIA: The cancer is confined to the pancreas and is bigger than 4 cm. There is no involvement of nearby lymph nodes or distant sites.
Stage IIB: The cancer is confined to the pancreas and is not bigger than 2 cm, and has spread to not more than 3 nearby lymph nodes. Distant sites are not involved. The second type is where the cancer is confined to the pancreas and is larger than 2 cm but not more than 4 cm and it has spread to more than 3 nearby lymph nodes. The third type in this category is where the cancer is confined to the pancreas and is bigger than 4 cm and has spread to more than 3 nearby lymph nodes. Distant sites are not involved.
Stage III: The cancer is confined to the pancreas and is no bigger than 2 cm and has spread to more than 4 nearby lymph nodes. Distant sites are not involved. The second type is where the cancer is confined to the pancreas and is larger than 2 cm but not more than 4 cm and it has spread to more than 4 nearby lymph nodes. No distant sites are involved. The third type in this category is where the cancer is confined to the pancreas and is bigger than 4 cm and has spread to more than 4 nearby lymph nodes. Distant sites are not involved. The fourth type is where the cancer is growing outside the pancreas and into nearby major blood vessels. The cancer may or may not have spread to nearby lymph nodes. Distant sites are not involved.
Stage IV: The cancer has spread to distant sites such as the liver, peritoneum (lining of the abdominal cavity), lungs or bones. It can be of any size and may or may not involve nearby lymph nodes.